Rare Diseases & Orphan Drug

Introduction: Gonococcal infections are a major part of sexually transmitted infections among MSM. The rising trend of gonococcal infections in male is alarming and screening of antibiotic resistance is important to treat them. The objective is to isolate gonococci and detect the resistance of gonococci by phenotypic methods from patients attending venereology department.

 

Method: All the patients with cervical discharge or urethral discharge attending venereology department were screened by grams stain and culture was done on Th ayir Martin medium. Antibiotic resistance was detected by disc diff usion method as per CLSI guidelines.

 

Results: A total of 50 gonococcal isolate were identifi ed from males with urethral discharge. None were isolated from females. Out of 50 isolates 60% (30) were B-lactamase producers and resistance to penicillin and 34% (17) to tetracycline. 64% (32) of isolates had developed chromosomal resistance to Ciprofl oxacin and 12% (6) were resistance to Azithromycin. 4% (2) of the isolate was resistant to Cephalosporins. One isolate was resistant to four drugs.

 

Conclusion: Th e isolation of gonococci from male has been increasing along with resistance to penicillins, fl uoroquinolone and tetracycline. Resistances to Cephalosporins are beginning to appear. Emergence of multidrug resistance makes treatment of gonococcal infections a challenge. Hence it is mandatory to screen for resistance and treat the infections so as to prevent spread of infections especially in male with multiple sex partners all of whose identity may not be known to treat the partner as well.